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Wyoming Cowboys Take on Colorado Buffaloes in Key Non-Conference Clash

The Wyoming Cowboys (2–1) travel to Boulder, Colorado to face the Colorado Buffaloes (1–2) in a pivotal non-conference college football matchup on Saturday, September 20, 2025, at 8:15 p.m. MT. The game will be broadcast live on ESPN and available via the ESPN App.

Team Insights:

  • Wyoming Cowboys: The Cowboys opened their season with wins over Akron and Northern Iowa before a home loss to Utah, moving to a 2–1 record. Wyoming looks to bounce back and build momentum following a challenging 3–9 campaign last year.
  • Colorado Buffaloes: Under head coach Deion Sanders, Colorado has faced early-season struggles, including a 36–20 loss to Houston in their Big 12 opener. The Buffaloes aim to regroup and capture a home victory in front of their fans.

Key Storylines:

  • Quarterback Spotlight: Colorado’s offense will rely on senior Kaidon Salter, a Liberty transfer who returns as the starter. Salter has completed 68.2% of passes for 261 yards and one touchdown, adding 67 rushing yards and two rushing scores, providing dual-threat capability to lead the Buffaloes.
  • Mascot Milestone: Fans will get a first look at Ralphie VII, Colorado’s new live buffalo mascot. Weighing 700 pounds, the one-year-old bison replaces Ralphie VI and was generously donated by the Beauprez Family from Eagle’s Wing Ranch near Steamboat Springs, Colorado.

Game Outlook:

Wyoming’s defense has been solid early in the season, but Colorado’s offense is expected to thrive at home. With a motivated Buffaloes squad looking to rebound from recent setbacks, Colorado holds the edge in this matchup.

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